Associação de Pacientes Canábicos do Estado de São Paulo - São Paulo - SP
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Associação de Pacientes Canabicos do Estado de São Paulo. Sua melhor experiência com cannabis. òleos, tinturas, pomadas, in natura
About Associação de Pacientes Canábicos do Estado de São Paulo
Newborn piglets exposed to acute hypoxia-ischemia (HI) received i.v. cannabidiol (HI + CBD) or vehicle (HI + VEH). In HI + VEH, 72 h post-HI brain activity as assessed by amplitude-integrated EEG (aEEG) had only recovered to 42 ± 9% of baseline, near-infrared spectroscopy (NIRS) parameters remained lower than normal, and neurobehavioral performance was abnormal (27.8 ± 2.3 points, normal 36). In the brain, there were fewer normal and more pyknotic neurons, while astrocytes were less numerous and swollen. Cerebrospinal fluid concentration of neuronal-specific enolase (NSE) and S100β protein and brain tissue percentage of TNFα(+) cells were all higher. In contrast, in HI + CBD, aEEG had recovered to 86 ± 5%, NIRS parameters increased, and the neurobehavioral score normalized (34.3 ± 1.4 points). HI induced histological changes, and NSE and S100β concentration and TNFα(+) cell increases were suppressed by CBD. In conclusion, post-HI administration of CBD protects neurons and astrocytes, leading to histological, functional, biochemical, and neurobehavioral improvements.
Contact Associação de Pacientes Canábicos do Estado de São Paulo
| Address : | 839 - Vila Mariana, São Paulo - SP, 04014-012, Brazil |
| Phone : | 📞 +9899 |
| Postal code : | 04014-012 |
| Website : | http://www.apcesp.com.br/ |
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